Abstract
We sought to determine whether pretreatment low pol replication capacity (polRC) is associated with CD4 T-cell count gains during antiretroviral therapy (ART). Patients were recruited at north American and Australian sites. Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses.
Publication types
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Multicenter Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / therapeutic use*
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Antiretroviral Therapy, Highly Active
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CD4 Lymphocyte Count
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Follow-Up Studies
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Genes, pol / physiology*
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HIV Infections / drug therapy*
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / genetics
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HIV-1 / isolation & purification
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HIV-1 / physiology*
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Humans
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Prognosis
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RNA, Viral / blood
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Virus Replication / genetics
Substances
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Anti-HIV Agents
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RNA, Viral