Peri-infarct ischemia determined by cardiovascular magnetic resonance evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy

J Cardiovasc Magn Reson. 2006;8(6):773-9. doi: 10.1080/10976640600737615.

Abstract

Background: We assessed whether cardiovascular magnetic resonance imaging (CMR) of peri-infarct ischemia provides prognostic information in severe ischemic cardiomyopathy (ICM) patients referred for revascularization.

Methods: Twenty-one patients with severe ICM were recruited prospectively for combined stress adenosine perfusion, late gadolinium enhancement, and rest perfusion studies. The patients were followed for in-hospital and post-discharge cardiovascular events.

Results: During 12+/- 9.8 months follow-up, 67% of the patients with peri-infarct ischemia and 13% of the patients without peri-infarct ischemia had cardiovascular events (p = 0.03). CONCLUSION. In severe ICM patients, the presence of peri-infarct ischemia was associated with a higher incidence of cardiovascular events.

MeSH terms

  • Adenosine
  • Adult
  • Aged
  • Cardiomyopathies / pathology
  • Contrast Media
  • Coronary Circulation*
  • Female
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging, Cine*
  • Male
  • Middle Aged
  • Myocardial Infarction / pathology*
  • Myocardial Ischemia / pathology*
  • Myocardium / pathology
  • Prognosis
  • Prospective Studies
  • Vasodilator Agents

Substances

  • Contrast Media
  • Vasodilator Agents
  • Gadolinium DTPA
  • Adenosine