Abstract
Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method. We demonstrate a strong correlation between the quantitative measures of in vitro amphotericin B susceptibility and the quantitative response observed in patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / microbiology*
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Amphotericin B / pharmacology*
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Amphotericin B / therapeutic use
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use
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Cryptococcus neoformans / drug effects*
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Humans
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Meningitis, Cryptococcal / drug therapy
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Meningitis, Cryptococcal / microbiology*
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Microbial Sensitivity Tests
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Regression Analysis
Substances
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Antifungal Agents
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Amphotericin B