Abstract
The synthesis of two new diastereomeric 6-amino-3-azabicyclo[3.2.1]octane-6-carboxylic acids exo- and endo-8,9 is reported using exo- and endo-norbornene amino acids as chiral building blocks. This method provides a fast access to optically pure amino acids 8 and 9 which can be considered both alpha,gamma- and alpha,delta-diamino acids containing sterical constraints and characterized by alpha,alpha-disubstitution.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids, Diamino / chemical synthesis*
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Amino Acids, Diamino / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Carboxylic Acids / chemical synthesis*
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Carboxylic Acids / chemistry
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Molecular Structure
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Norbornanes / chemistry
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Stereoisomerism
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Time Factors
Substances
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Amino Acids, Diamino
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Bridged Bicyclo Compounds, Heterocyclic
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Carboxylic Acids
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Norbornanes