Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort

J Neurovirol. 2006 Oct;12(5):387-91. doi: 10.1080/13550280600915339.

Abstract

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / psychology
  • Aging
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count*
  • Cognition Disorders / epidemiology*
  • Cognition Disorders / immunology*
  • Cohort Studies
  • Ethnicity
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / immunology*
  • HIV Infections / psychology*
  • Hawaii
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Treatment Outcome