Abstract
The in vitro activity of retapamulin was determined and compared to that of topical and community antibiotics. The MIC(90)s of retapamulin against Staphylococcus aureus and Streptococcus pyogenes were 0.12 microg/ml and 0.016 microg/ml, respectively. Retapamulin has a low propensity to select resistance and produces an in vitro postantibiotic effect.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Infective Agents, Local / pharmacology*
-
Bacteria / drug effects*
-
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
-
Diterpenes / pharmacology
-
Drug Resistance, Bacterial
-
Haemophilus influenzae / drug effects
-
Humans
-
Microbial Sensitivity Tests
-
Moraxella catarrhalis / drug effects
-
Mupirocin / pharmacology
-
Pleuromutilins
-
Polycyclic Compounds
-
Skin Diseases, Bacterial / microbiology
-
Staphylococcus / drug effects
-
Streptococcus / drug effects
Substances
-
Anti-Infective Agents, Local
-
Bridged Bicyclo Compounds, Heterocyclic
-
Diterpenes
-
Polycyclic Compounds
-
retapamulin
-
Mupirocin