Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae

Glenn A Pankuch; Dianne Hoellman; André Bryskier; John Lowther; Peter C Appelbaum

doi:10.1128/AAC.00587-06

Effects of various media on the activity of NXL103 (formerly XRP 2868), a new oral streptogramin, against Haemophilus influenzae

Antimicrob Agents Chemother. 2006 Nov;50(11):3914-6. doi: 10.1128/AAC.00587-06.

Authors

Glenn A Pankuch¹, Dianne Hoellman, André Bryskier, John Lowther, Peter C Appelbaum

Affiliation

¹ Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.

Abstract

The activity of NXL103 against 108 strains of Haemophilus influenzae was tested using Haemophilus test media (HTM) obtained from various sources. With the exception of those obtained with stored HTM, MICs did not differ significantly, with MIC(50) and MIC(90) values of 0.5 and 0.5 to 1 microg/ml, respectively, in each medium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacokinetics
Anti-Bacterial Agents / pharmacology*
Culture Media
Dose-Response Relationship, Drug
Drug Combinations
Haemophilus influenzae / drug effects*
Microbial Sensitivity Tests
Streptogramin A / pharmacokinetics
Streptogramin A / pharmacology*
Streptogramin B / pharmacokinetics
Streptogramin B / pharmacology*
Streptogramins / pharmacokinetics
Streptogramins / pharmacology*

Substances

Anti-Bacterial Agents
Culture Media
Drug Combinations
Streptogramins
flopristin, linopristin drug combination
Streptogramin B
Streptogramin A