Abstract
Macrolides, which are widely prescribed and seldom produce hypersensitivity reactions, are considered to be safe drugs. We present five patients with generalized skin reactions due to erythromycin and/or spiramycin, proved by oral challenge tests. One patient showed reactions to both erythromycin and spiramycin. All skin prick and patch tests and histamine release tests with both macrolides were negative.
MeSH terms
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Adult
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / pharmacology
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Erythromycin / adverse effects
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Erythromycin / pharmacology
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Female
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Histamine Release / drug effects
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Histamine Release / physiology
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Humans
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Immunoglobulin E / analysis
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Middle Aged
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Skin / drug effects*
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Skin / pathology
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Skin Diseases / chemically induced
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Skin Diseases / pathology
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Skin Diseases / physiopathology
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Skin Physiological Phenomena
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Skin Tests
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Spiramycin / adverse effects
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Spiramycin / pharmacology
Substances
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Anti-Bacterial Agents
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Immunoglobulin E
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Erythromycin
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Spiramycin