Thermodynamics of the cyclophilin-A/cyclosporin-A interaction: a direct comparison of parameters determined by surface plasmon resonance using Biacore T100 and isothermal titration calorimetry

Anal Biochem. 2006 Dec 15;359(2):285-7. doi: 10.1016/j.ab.2006.08.038. Epub 2006 Sep 22.

Authors

Martin A Wear¹, Malcolm D Walkinshaw

Affiliation

¹ The Centre for Translational and Chemical Biology, The University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.

PMID: 17069746
DOI: 10.1016/j.ab.2006.08.038

No abstract available

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques
Calorimetry / methods*
Cyclophilins / chemistry*
Cyclosporine / chemistry*
Drug Interactions
Kinetics
Protein Binding
Surface Plasmon Resonance / methods*
Thermodynamics
Titrimetry / methods

Substances

Cyclosporine
Cyclophilins

Grants and funding