A computational model for motor pattern switching between taste-induced ingestion and rejection oromotor behaviors

J Comput Neurosci. 2007 Apr;22(2):223-38. doi: 10.1007/s10827-006-0009-3.

Abstract

The mechanism of switching activity patterns in a central pattern generator is fundamental to the generation of diverse motor behaviors. Based on what is known about a brainstem substrate mediating the oral components of ingestion and rejection, we use computational techniques to construct a hypothetical multifunctional network that switches between the motor outputs of ingestion (licking) and rejection (gaping). The network was constructed using single-compartment conductance-based models for individual neurons based on Hodgkin-Huxley formalism. Using a fast-slow reduction and geometric analysis we describe a mechanism for pattern switching between licks and gapes. The model supports the hypothesis that a single configuration of network connections can produce both activity patterns. It further predicts that prolonged inhibition of some network neurons could lead to a switch in network activity from licks to gapes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Computer Simulation*
  • Deglutition / physiology
  • Eating / physiology*
  • Feeding Behavior
  • Membrane Potentials / physiology
  • Models, Biological*
  • Motor Activity / physiology*
  • Motor Neurons / physiology
  • Stomatognathic System / physiology*
  • Taste / physiology*