Abstract
The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.
MeSH terms
-
Administration, Oral
-
Animals
-
Antioxidants / administration & dosage
-
Antioxidants / isolation & purification
-
Antioxidants / therapeutic use*
-
Blood Glucose / analysis
-
Body Weight / drug effects
-
Catalase / metabolism
-
Diabetes Mellitus, Experimental / chemically induced
-
Diabetes Mellitus, Experimental / metabolism
-
Diabetes Mellitus, Experimental / prevention & control*
-
Drinking / drug effects
-
Eating / drug effects
-
Glutathione / metabolism
-
Heliotropium / chemistry*
-
Hypercholesterolemia / chemically induced
-
Hypercholesterolemia / metabolism
-
Hypercholesterolemia / prevention & control
-
Hypertriglyceridemia / chemically induced
-
Hypertriglyceridemia / metabolism
-
Hypertriglyceridemia / prevention & control
-
Hypoglycemic Agents / administration & dosage
-
Hypoglycemic Agents / isolation & purification
-
Hypoglycemic Agents / therapeutic use*
-
Hypolipidemic Agents / administration & dosage
-
Hypolipidemic Agents / isolation & purification
-
Hypolipidemic Agents / therapeutic use*
-
Liver / drug effects
-
Liver / metabolism
-
Male
-
Phytotherapy / methods
-
Plant Extracts / administration & dosage
-
Plant Extracts / chemistry
-
Plant Extracts / therapeutic use*
-
Rats
-
Rats, Wistar
-
Streptozocin
-
Superoxide Dismutase / metabolism
-
Thiobarbituric Acid Reactive Substances / metabolism
-
Tolbutamide / pharmacology
Substances
-
Antioxidants
-
Blood Glucose
-
Hypoglycemic Agents
-
Hypolipidemic Agents
-
Plant Extracts
-
Thiobarbituric Acid Reactive Substances
-
Streptozocin
-
Tolbutamide
-
Catalase
-
Superoxide Dismutase
-
Glutathione