Long-term prognosis of primary retroperitoneal soft tissue sarcoma

Eur J Surg Oncol. 2007 Mar;33(2):234-8. doi: 10.1016/j.ejso.2006.09.020. Epub 2006 Oct 31.

Abstract

Aims: To evaluate the result of treatment and long-term outcome of a population-based cohort of patients with retroperitoneal soft tissue sarcoma (RSTS).

Methods: Between 1 January 1989 and 1 January 1994, 143 patients diagnosed as having primary RSTS were selected from a national pathology database (PALGA) in the Netherlands. In this population-based group of patients, the result of surgery, overall survival (OS) and disease-free survival (DFS) were analysed as well as factors affecting OS and DFS. Median follow-up was 10.2 years.

Results: Operative treatment resulted in a complete tumour resection in 55% of the patients (n=78), low- and intermediate-grade tumours were more often completely resected than high-grade tumours (P=0.016). Five- and 10-year cumulative OS was 39% and 21%, respectively, while DFS was 22% and 17%, respectively. In a multivariate analysis low malignancy grade (P=0.017) and a complete tumour resection (P<0.001) were associated with better OS.

Conclusions: Complete tumour resection and low malignancy grade were independent favourable prognosticators. However, these factors were related too, since surgical success was influenced by malignancy grade.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Netherlands / epidemiology
  • Population Surveillance
  • Prognosis
  • Retroperitoneal Neoplasms / epidemiology*
  • Retroperitoneal Neoplasms / pathology
  • Retroperitoneal Neoplasms / radiotherapy
  • Retroperitoneal Neoplasms / surgery
  • Retrospective Studies
  • Risk Factors
  • Sarcoma / epidemiology*
  • Sarcoma / pathology
  • Sarcoma / radiotherapy
  • Sarcoma / surgery
  • Survival Rate / trends
  • Time Factors