Abstract
In three young girls with isosexual precocity and fibrous dysplasia of bones, plasma gonadotropins (LH and FSH) response to releasing hormone (LH-RH) has been much under the mean response in true female precocious puberty. These data and those previously reported in the literature suggest that MacCune-Albright's syndrome correlates to an hypothalamo-pituitary dysfunction rather than to a true prematurity.
MeSH terms
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17-Hydroxycorticosteroids / urine
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17-Ketosteroids / urine
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Age Determination by Skeleton
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Child
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Child, Preschool
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Endocrine System Diseases / complications
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Endocrine System Diseases / drug therapy
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Estradiol / blood
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Estrone / blood
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Female
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Fibrous Dysplasia of Bone / complications*
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Fibrous Dysplasia of Bone / drug therapy
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Gonadotropin-Releasing Hormone / analysis
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Gonadotropins, Pituitary / metabolism*
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Gonadotropins, Pituitary / urine
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Growth Hormone / therapeutic use
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Humans
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Infant
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Medroxyprogesterone / therapeutic use
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Pigmentation Disorders / complications
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Pigmentation Disorders / drug therapy
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Puberty, Precocious / complications*
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Puberty, Precocious / drug therapy
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Syndrome
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Thyroxine / therapeutic use
Substances
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17-Hydroxycorticosteroids
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17-Ketosteroids
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Gonadotropins, Pituitary
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Estrone
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Gonadotropin-Releasing Hormone
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Estradiol
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Growth Hormone
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Medroxyprogesterone
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Thyroxine