Abstract
Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cryptococcus neoformans / pathogenicity
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Epithelial Cells / drug effects*
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Epithelial Cells / metabolism
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Humans
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Interleukin-8 / metabolism*
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Lipopolysaccharide Receptors / metabolism*
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Polysaccharides / pharmacology*
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Pulmonary Alveoli / drug effects*
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Pulmonary Alveoli / microbiology
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Pulmonary Alveoli / pathology
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Receptors, Cell Surface / physiology*
Substances
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Interleukin-8
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Lipopolysaccharide Receptors
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Polysaccharides
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Receptors, Cell Surface
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glucuronoxylomannan