Abstract
Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification*
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Phenylpropionates / pharmacology
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rabbits
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Sarcoplasmic Reticulum Calcium-Transporting ATPases / antagonists & inhibitors
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Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism
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Thapsia / chemistry*
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Thapsigargin / chemistry*
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Thapsigargin / isolation & purification
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Thapsigargin / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Phenylpropionates
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Plant Extracts
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Thapsigargin
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Sarcoplasmic Reticulum Calcium-Transporting ATPases