Abstract
To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls. Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Brain / metabolism
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Brain / physiopathology
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Brain Chemistry / genetics
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Case-Control Studies
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DNA Mutational Analysis
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Female
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Gene Frequency / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genetic Variation / genetics
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Germany / epidemiology
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Haplotypes
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Humans
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Male
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Migraine with Aura / epidemiology
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Migraine with Aura / genetics*
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Migraine with Aura / physiopathology
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Mutation / genetics
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Polymorphism, Genetic / genetics*
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins / genetics*
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Serotonin Plasma Membrane Transport Proteins / metabolism
Substances
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Serotonin