Doramectin and albendazole resistance in sheep in The Netherlands

Vet Parasitol. 2007 Mar 15;144(1-2):180-3. doi: 10.1016/j.vetpar.2006.09.031. Epub 2006 Nov 17.

Abstract

A faecal egg count reduction test was conducted on a sheep farm with suspected avermectin resistance. Five groups of 10 sheep were formed. Group 1 was the untreated control group. Groups 2-5 were treated according to weight with the recommended dose of, respectively, levamisole, doramectin, moxidectin or albendazole. Resistance was found in the sheep treated with doramectin (15% efficacy) and albendazole (87% efficacy). Levamisole and moxidectin were 100 and 99% effective, respectively. Larval identification of the faecal cultures of the doramectin-treated sheep revealed 100% Haemonchus contortus larvae. After albendazole treatment, 77% of the cultured larvae were H. contortus and 23% Teladorsagia/Trichostrongylus. Because there is a lot of trade in sheep on the farm, it is probable that the resistant worms were introduced with livestock from other farms than being selected on the farm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albendazole / therapeutic use
  • Animals
  • Anthelmintics / therapeutic use*
  • Dose-Response Relationship, Drug
  • Drug Resistance*
  • Feces / parasitology
  • Helminthiasis, Animal / drug therapy*
  • Ivermectin / analogs & derivatives
  • Ivermectin / therapeutic use
  • Netherlands / epidemiology
  • Parasite Egg Count / veterinary
  • Parasitic Sensitivity Tests / veterinary
  • Sheep
  • Sheep Diseases / drug therapy*
  • Treatment Outcome

Substances

  • Anthelmintics
  • Ivermectin
  • Albendazole
  • doramectin