Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata

N Schäfer; B Blaumeiser; T Becker; Y Freudenberg-Hua; S Hanneken; S Eigelshoven; C Schmael; J Lambert; J De Weert; R Kruse; M M Nöthen; R C Betz

doi:10.1111/j.1744-313X.2006.00633.x

Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata

Int J Immunogenet. 2006 Dec;33(6):393-5. doi: 10.1111/j.1744-313X.2006.00633.x.

Authors

N Schäfer¹, B Blaumeiser, T Becker, Y Freudenberg-Hua, S Hanneken, S Eigelshoven, C Schmael, J Lambert, J De Weert, R Kruse, M M Nöthen, R C Betz

Affiliation

¹ Institute of Human Genetics, University of Bonn, Bonn, Germany.

PMID: 17117947
DOI: 10.1111/j.1744-313X.2006.00633.x

Abstract

A functional variant in the Fc receptor-like 3 (FCRL3) gene has been implicated in susceptibility to autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroid disease. Investigating a large case-control sample of patients with alopecia areata (AA), we found no evidence for the involvement of FCRL3 in susceptibility to AA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Alopecia Areata / genetics*
Case-Control Studies
Child
Cytosine
Female
Genetic Predisposition to Disease*
Genetic Variation
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptors, Immunologic / genetics*
Thymine

Substances

FCRL3 protein, human
Receptors, Immunologic
Cytosine
Thymine