Abstract
A series of multinuclear macrocyclic polyamine metal (Zn(2+), Cu(2+), Co(2+)) complexes containing chiral dipeptide linkage were synthesized and used as artificial nuclease enzyme model. The interaction between the complexes and plasmid DNA (pUC19) was studied, and the results revealed that these complexes could act as powerful catalysts for the cleavage of plasmid DNA under physiological conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Cobalt / chemistry
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Cobalt / pharmacology
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Copper / chemistry
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Copper / pharmacology
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DNA / drug effects*
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Deoxyribonucleases / chemistry
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Indicators and Reagents
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / pharmacology*
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Magnetic Resonance Spectroscopy
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Plasmids / drug effects*
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Polyamines / chemical synthesis*
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Polyamines / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Zinc / chemistry
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Zinc / pharmacology
Substances
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Indicators and Reagents
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Macrocyclic Compounds
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Polyamines
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Cobalt
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Copper
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DNA
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Deoxyribonucleases
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Zinc