We report the clinical and histopathological features of 2 cases of Gamna-Gandy bodies located in the spleen. The diagnosis was made by the presence of circumscribed nodules containing dark brown rod-shaped and "bamboo-shaped" fibrotic structures. These structures were positive with Perls and von Kossa staining. Differential diagnosis includes filamentous mycoses such as mucormycosis and phaeohyphomycosis. Gamna-Gandy nodules can be isolated or these bodies can be observed associated with another lesion, particularly, a tumor.