Direct comparison of peripheral T-cell lymphomas with their B-cell counterpart

Acta Haematol. 1991;85(4):179-83. doi: 10.1159/000204887.

Abstract

The aim of this study was to determine the effect of immunophenotype on the clinical characteristics and prognosis of 144 adult Chinese patients with non-Hodgkin's lymphomas. Those entities with well-recognised immunophenotype and clinical characteristics were excluded. Significantly more patients with T-cell lymphomas had B symptoms (52 vs. 30%, p = 0.05) and fewer had bulky disease (7 vs. 25%, p = 0.04). Extranodal involvements of liver, spleen, marrow, nasal region and skin were significantly more common in T-cell lymphomas. On the other hand, gastro-intestinal involvement was more commonly seen in B-cell tumours. Induction chemotherapy of comparable intensity was used in treating these patients. The immunophenotype did not appear to affect significantly their prognosis.

Publication types

  • Comparative Study

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / therapeutic use
  • China
  • Cyclophosphamide / therapeutic use
  • Dexamethasone / therapeutic use
  • Doxorubicin / therapeutic use
  • Female
  • Humans
  • Immunophenotyping
  • Leucovorin / therapeutic use
  • Lomustine / therapeutic use
  • Lymphoma, B-Cell* / drug therapy
  • Lymphoma, B-Cell* / mortality
  • Lymphoma, B-Cell* / pathology
  • Lymphoma, T-Cell* / drug therapy
  • Lymphoma, T-Cell* / mortality
  • Lymphoma, T-Cell* / pathology
  • Male
  • Methotrexate / therapeutic use
  • Middle Aged
  • Prednisone / therapeutic use
  • Procarbazine / therapeutic use
  • Survival Rate
  • Vinblastine / therapeutic use
  • Vincristine / therapeutic use

Substances

  • Bleomycin
  • Procarbazine
  • Vincristine
  • Vinblastine
  • Lomustine
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • Leucovorin
  • Prednisone
  • Methotrexate

Supplementary concepts

  • CHOP-B protocol
  • COPP protocol
  • CVPP protocol
  • M-BACOD protocol