Schistosomal colitis without granuloma formation in a kidney transplant recipient

Nat Clin Pract Gastroenterol Hepatol. 2006 Dec;3(12):700-4. doi: 10.1038/ncpgasthep0655.

Abstract

Background: A 40-year-old male from the White Nile region in Sudan, who had received a kidney transplant 6 years previously, presented with fever, lower abdominal pain and diarrhea stained with blood of 5 months duration. He was on immunosuppressive maintenance therapy, consisting of ciclosporin 75 mg twice daily, prednisolone 10 mg once daily, and azathioprine 75 mg once daily.

Investigations: Laboratory investigations, liver function tests, renal function tests, stool microscopy, stool culture, abdominal ultrasound, and colonoscopy.

Diagnosis: Severe, left-sided colitis due to Schistosoma mansoni infection, without granuloma formation.

Management: Oral antischistosomal therapy with praziquantel at a dose of 40 mg/kg body weight.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Humans
  • Immunocompromised Host*
  • Kidney Transplantation*
  • Male
  • Schistosomiasis mansoni / diagnosis*
  • Schistosomiasis mansoni / drug therapy
  • Schistosomiasis mansoni / immunology