International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor

Pharmacol Rev. 2006 Dec;58(4):742-59. doi: 10.1124/pr.58.4.6.

Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Constitutive Androstane Receptor
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Humans
  • Liver X Receptors
  • Mutation
  • Orphan Nuclear Receptors
  • Pregnane X Receptor
  • Receptors, Calcitriol / genetics
  • Receptors, Calcitriol / physiology*
  • Receptors, Cytoplasmic and Nuclear / classification
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Receptors, Steroid / genetics
  • Receptors, Steroid / physiology*
  • Terminology as Topic
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Constitutive Androstane Receptor
  • DNA-Binding Proteins
  • Liver X Receptors
  • NR1H3 protein, human
  • Orphan Nuclear Receptors
  • Pregnane X Receptor
  • Receptors, Calcitriol
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Transcription Factors
  • farnesoid X-activated receptor