One-pot synthesis of 2,3-dihydro-pyrrolopyridinones using in situ generated formimines

Org Lett. 2006 Dec 7;8(25):5889-92. doi: 10.1021/ol062577c.

Abstract

A novel one-pot methodology is described for the synthesis of functionalized pyrrolopyridinones using in situ generated formimines and an ortho-lithiated pyridinecarboxamide species. Depending on the reaction conditions, this procedure allows versatile access to aminomethylated pyridinecarboxamides, 2,3-dihydro-pyrrolopyridinones, or 1,1-dialkylated 2,3-dihydro-pyrrolopyridinone derivatives. [reaction: see text]