Abstract
Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Diabetes, Gestational / metabolism*
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Female
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Fetal Blood / chemistry*
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Fetal Macrosomia / blood*
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Fetal Macrosomia / metabolism
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Humans
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Infant, Newborn
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Insulin / blood*
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Leukocytes / chemistry*
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Pregnancy
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Protein Prenylation*
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Proto-Oncogene Proteins p21(ras) / metabolism*
Substances
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Insulin
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Proto-Oncogene Proteins p21(ras)