Crystal structure and DNA interaction of the facial-type rac-tris[2-(aminomethyl)benzimidazole]cobalt(III) complex

Inorg Chem. 2006 Dec 11;45(25):10031-3. doi: 10.1021/ic061292t.

Abstract

rac-[Co(ambi)3]Cl3.3H2O corresponds to a tris-chelate complex bearing 2-(aminomethyl)benzimidazole (ambi) ligands bound to the Co(III) ion in a facial-type fashion. The high metal q/r ratio and electronic delocalization between coordination heterocyclic functionalities can provide powerful tools to minimize DNA condensation, which arises from the neutralization of the negatively charged sugar phosphate backbone in the presence of multivalent [Co(ambi)3]3+.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chelating Agents / chemistry*
  • Chelating Agents / metabolism
  • Crystallography, X-Ray
  • DNA / chemistry*
  • DNA / metabolism
  • Microscopy, Atomic Force
  • Nucleic Acid Conformation
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Stereoisomerism
  • Sugar Phosphates / chemistry
  • Sugar Phosphates / metabolism

Substances

  • Chelating Agents
  • Organometallic Compounds
  • Sugar Phosphates
  • tris(2-(aminomethyl)benzimidazole)cobalt(III)
  • DNA