A new sesquiterpene ester inhibiting no production from the fruits of Celastrus orbiculatus

J Asian Nat Prod Res. 2006 Dec;8(8):739-42. doi: 10.1080/10286020412331286498.

Abstract

A new beta-dihydroagarofuran sesquiterpene ester, 1beta,2beta,6alpha, 13-tetraacetoxy-9alpha-cinnamoyloxy-beta-dihydroagarofuran (1), and the known compound 1beta,6alpha,13-triacetoxy-9alpha-benzoyloxy-beta-dihydroagarofuran (2), have been isolated from the fruits of Celastrus orbiculatus Thunb. Their structures have been elucidated on the basis of spectroscopic methods. Compound 1 shows moderate activity of inhibiting LPS-induced nitric oxide production in murine macrophage RAW264.7 cells, with an IC50 of 55.4 microM.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Celastrus / chemistry*
  • Cell Line
  • China
  • Chromatography, High Pressure Liquid
  • Esters / chemistry
  • Esters / isolation & purification
  • Esters / pharmacology
  • Fruit / chemistry*
  • Furans / chemistry*
  • Furans / isolation & purification
  • Furans / pharmacology
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide / antagonists & inhibitors
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • 1beta,2beta,6alpha, 13-tetraacetoxy-9alpha-cinnamoyloxy-beta-dihydroagarofuran
  • Esters
  • Furans
  • Sesquiterpenes
  • Nitric Oxide