Hypervirulence of a rough variant of the Mycobacterium abscessus type strain

E Catherinot; J Clarissou; G Etienne; F Ripoll; J-F Emile; M Daffé; C Perronne; C Soudais; J-L Gaillard; M Rottman

doi:10.1128/IAI.00835-06

Hypervirulence of a rough variant of the Mycobacterium abscessus type strain

Infect Immun. 2007 Feb;75(2):1055-8. doi: 10.1128/IAI.00835-06. Epub 2006 Dec 4.

Authors

E Catherinot¹, J Clarissou, G Etienne, F Ripoll, J-F Emile, M Daffé, C Perronne, C Soudais, J-L Gaillard, M Rottman

Affiliation

¹ Laboratoire de Microbiologie, Hôpital Raymond Poincaré, 104 Bd Raymond Poincaré, 92380 Garches, France.

Abstract

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Glycolipids / biosynthesis
Glycopeptides / biosynthesis
Macrophages / immunology
Mice
Mice, Inbred C57BL
Mutation
Mycobacterium Infections, Nontuberculous / immunology
Mycobacterium Infections, Nontuberculous / microbiology*
Mycobacterium chelonae / immunology
Mycobacterium chelonae / pathogenicity*
Mycobacterium chelonae / physiology
Survival Analysis
Tumor Necrosis Factor-alpha / biosynthesis
Virulence

Substances

Glycolipids
Glycopeptides
Tumor Necrosis Factor-alpha