Abstract
The macrolide FK-506, produced by Streptomyces tsukubaensis, is effective in sensitizing a multidrug resistant strain of Chinese hamster ovary cells to the cytotoxic action of vinblastine. FK-506 also promotes Adriamycin accumulation into both wild type and resistant cell lines. FK-506 may be a useful drug to enhance the effectiveness of anti-tumour cytotoxic drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Biological Transport / drug effects
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Cell Line
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Cell Survival
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Cricetinae
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Cricetulus
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Dose-Response Relationship, Drug
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Doxorubicin / metabolism
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Drug Resistance*
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Immunosuppressive Agents / pharmacology*
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Tacrolimus
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Vinblastine / pharmacology
Substances
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Anti-Bacterial Agents
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Immunosuppressive Agents
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Vinblastine
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Doxorubicin
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Tacrolimus