Abstract
Diarrhoea-related morbidity is reduced by zinc supplementation in HIV-1-infected children. The mechanisms of this effect are largely undefined. We provide evidence for role for Tat (transactivating peptide produced by HIV-1) in the pathogenesis of diarrhoea in AIDS patients. In this study we showed that zinc, preventing Tat-induced fluid secretion, directly limits a specific mechanism of HIV-1-related diarrhoea. Our data support a 'zinc approach' in adjunct to specific antiretroviral therapy in HIV-1-infected children.
MeSH terms
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Child
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Diarrhea / drug therapy*
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Diarrhea / etiology*
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Diarrhea / physiopathology
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Gene Products, tat / metabolism
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HIV Infections / complications*
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HIV Infections / drug therapy
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HIV Infections / physiopathology
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HIV-1*
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Humans
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / metabolism
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Intestinal Mucosa / virology
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Ions
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Micronutrients / therapeutic use*
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Zinc / therapeutic use*
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tat Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, tat
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Ions
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Micronutrients
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tat Gene Products, Human Immunodeficiency Virus
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Zinc