Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

Abdelselam Ali; Marianne Bliese; Jo-Anne M Rasmussen; Roger M Sargent; Simon Saubern; David G Sawutz; John S Wilkie; David A Winkler; Kevin N Winzenberg; Ruth C J Woodgate

doi:10.1016/j.bmcl.2006.11.043

Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea)

Bioorg Med Chem Lett. 2007 Feb 15;17(4):993-7. doi: 10.1016/j.bmcl.2006.11.043. Epub 2006 Nov 17.

Authors

Abdelselam Ali¹, Marianne Bliese, Jo-Anne M Rasmussen, Roger M Sargent, Simon Saubern, David G Sawutz, John S Wilkie, David A Winkler, Kevin N Winzenberg, Ruth C J Woodgate

Affiliation

¹ CSIRO, Molecular and Health Technologies, Bayview Avenue, Clayton, Vic. 3168, Australia.

PMID: 17150358
DOI: 10.1016/j.bmcl.2006.11.043

Abstract

A series of 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives were synthesized and evaluated for in vitro activity against the endoparasite Haemonchus contortus and the ectoparasite Ctenocephalides felis. Some compounds had significant in vitro activity against these parasites.

MeSH terms

Acrylonitrile / analogs & derivatives*
Acrylonitrile / chemical synthesis
Acrylonitrile / pharmacology
Animals
Antinematodal Agents / chemical synthesis*
Antinematodal Agents / pharmacology*
Antiparasitic Agents / chemical synthesis*
Antiparasitic Agents / pharmacology*
Cats
Haemonchus / drug effects*
Insecticides / chemical synthesis*
Insecticides / pharmacology*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Siphonaptera / physiology*
Structure-Activity Relationship

Substances

(Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile
Antinematodal Agents
Antiparasitic Agents
Insecticides
Acrylonitrile