Abstract
A pyrrolepolyamide-deoxyguanosine hybrid using the 3-aminopropyl linker (GAP) was designed and synthesized on the basis of previously reported results of a pyrrolepolyamide-adenosine hybrid (Apy) and a pyrrolepolyamide-deoxyguanoside hybrid using the 3-aminopropionyl linker (GBP). An evaluation of the DNA binding sequence selectivity of GAP was performed by analysis of CD spectra and Tm values using three DNA duplexes. It was shown that GAP possessed greater binding specificity than distamycin A, netropsin, Apy and GBP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry
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Circular Dichroism
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / analysis
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Deoxyguanosine / chemical synthesis
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Deoxyguanosine / chemistry
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Nucleosides / analysis*
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Pyrroles / analysis*
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry
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Pyrrolidines / chemistry
Substances
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Amines
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N(2)-(3-(4-(4-(4-formylamino-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)-1-methylpyrrole-2-carboxamido)propyl)deoxyguanosine
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Nucleosides
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Pyrroles
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Pyrrolidines
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Deoxyguanosine