Synthesis and base recognition ability of oligoribonucleotides incorporating 2'-O-methyl-3-deazaguanosine

Kohji Seio; Takeshi Sasami; Mitsuo Sekine

doi:10.1093/nass/48.1.65

Synthesis and base recognition ability of oligoribonucleotides incorporating 2'-O-methyl-3-deazaguanosine

Nucleic Acids Symp Ser (Oxf). 2004:(48):65-6. doi: 10.1093/nass/48.1.65.

Authors

Kohji Seio¹, Takeshi Sasami, Mitsuo Sekine

Affiliation

¹ Frontier Collaborative Research Center, Tokyo Institute of Technology, Nagatsuda, Midoriku, Yokohama 226-8503, Japan.

PMID: 17150480
DOI: 10.1093/nass/48.1.65

Abstract

2'-O-methyl-oligoribonucleotides incorporating a 3-deazaguanine (3DG) were synthesized. Melting temperature (Tm value) analysis indicates the stability and base discriminating ability of the 2'-O-methyl-RNA/RNA duplex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Pair Mismatch
Base Pairing*
Guanosine / analogs & derivatives*
Guanosine / chemistry
Oligoribonucleotides / chemical synthesis*
Oligoribonucleotides / chemistry*

Substances

2'-O-methyl-3-deazaguanosine
Oligoribonucleotides
Guanosine
3-deazaguanosine