Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barré syndrome

J Neuroimmunol. 2007 Jan;182(1-2):177-84. doi: 10.1016/j.jneuroim.2006.10.015. Epub 2006 Dec 5.

Abstract

The capacity of ganglioside-specific autoantibodies to recruit leukocyte effector functions was studied. Serum samples from 87 patients with Guillain-Barré (GBS) or Miller Fisher syndrome (MFS), containing GM1-, GQ1b-, or GD1b-specific IgG or IgA, were tested for leukocyte activating capacity. Ganglioside-specific IgG antibodies generally induced leukocyte activation, irrespective of specificity. The magnitude of leukocyte degranulation correlated with GM1- and GQ1b-specific IgG titers, but not with disease severity. Finally, GM1-specific IgA activated leukocytes through the IgA receptor, FcalphaRI (CD89). Therefore, both ganglioside-specific IgG and IgA can recruit leukocyte effector functions, which may be relevant in the pathogenesis of GBS and MFS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibody Specificity
  • Antigens, CD / metabolism
  • Autoantibodies / immunology*
  • Cell Degranulation
  • Child
  • Child, Preschool
  • Female
  • G(M1) Ganglioside / immunology
  • Gangliosides / immunology*
  • Guillain-Barre Syndrome / blood
  • Guillain-Barre Syndrome / immunology*
  • Humans
  • Immunoglobulin A / immunology*
  • Immunoglobulin G / immunology*
  • Leukocytes / immunology*
  • Leukocytes / pathology
  • Male
  • Middle Aged
  • Miller Fisher Syndrome / blood
  • Miller Fisher Syndrome / immunology
  • Receptors, Fc / metabolism

Substances

  • Antigens, CD
  • Autoantibodies
  • Fc(alpha) receptor
  • Gangliosides
  • Immunoglobulin A
  • Immunoglobulin G
  • Receptors, Fc
  • ganglioside, GD1b
  • G(M1) Ganglioside
  • GQ1b ganglioside