Abstract
Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs<or=4 microg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology
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Diterpenes / chemical synthesis
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Diterpenes / chemistry
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Diterpenes / pharmacology
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Microbial Sensitivity Tests
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Pleuromutilins
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Polycyclic Compounds
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Staphylococcus aureus / drug effects
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Streptococcus pneumoniae / drug effects
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Diterpenes
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Polycyclic Compounds