Abstract
The formation of heterochromatin, which requires methylation of histone H3 at lysine 9 and the subsequent recruitment of chromodomain proteins such as heterochromatin protein HP1, serves as a model for the role of histone modifications and chromatin assembly in epigenetic control of the genome. Recent studies in Schizosaccharomyces pombe indicate that heterochromatin serves as a dynamic platform to recruit and spread a myriad of regulatory proteins across extended domains to control various chromosomal processes, including transcription, chromosome segregation and long-range chromatin interactions.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Chromatin Assembly and Disassembly
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Chromobox Protein Homolog 5
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / metabolism
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Ciliophora / genetics
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Ciliophora / metabolism
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Epigenesis, Genetic
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Heterochromatin / genetics*
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Heterochromatin / metabolism*
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Histones / genetics
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Histones / metabolism
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Mammals / genetics
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Mammals / metabolism
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Models, Genetic
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Plants / genetics
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Plants / metabolism
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RNA Interference
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Schizosaccharomyces / genetics
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Schizosaccharomyces / metabolism
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Schizosaccharomyces pombe Proteins / genetics
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Schizosaccharomyces pombe Proteins / metabolism
Substances
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Chromosomal Proteins, Non-Histone
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Heterochromatin
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Histones
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Schizosaccharomyces pombe Proteins
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Chromobox Protein Homolog 5