Abstract
This study was aimed at evaluating, on a limited number of benzopyran compounds, whether the insertion of an electron-rich spirocyclic substituent at the C4 carbon of the benzopyran molecular nucleus may improve the cardioprotective properties against ischemia. Some of the new compounds (1b, 2b, and 4b) exhibited interesting anti-ischemic properties without affecting significantly the blood pressure parameters.
MeSH terms
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Adenosine Triphosphate / pharmacology*
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Animals
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Aorta / drug effects
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Benzopyrans / chemical synthesis
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Cardiotonic Agents / pharmacology*
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Ischemia / drug therapy*
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L-Lactate Dehydrogenase / metabolism
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Mitochondria, Heart / drug effects*
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Mitochondria, Heart / metabolism
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Myocardial Reperfusion Injury / drug therapy*
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Potassium Channels / drug effects*
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Rats
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Vasodilation / drug effects
Substances
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Benzopyrans
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Cardiotonic Agents
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Potassium Channels
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Adenosine Triphosphate
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L-Lactate Dehydrogenase