Abstract
Two phases of CD4+ T-cell increases are seen soon after potent antiretroviral therapy (ART) is initiated. In this 72-week analysis of 101 subjects with sustained viral suppression, we estimate the inflection point between the 2 phases to be 10 weeks after treatment initiation. Higher pretreatment HIV-1 RNA levels were associated with steeper initial CD4+ T-cell increases, likely reflecting greater redistribution of cells from lymphoid tissue to the peripheral blood compartment.
Publication types
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Randomized Controlled Trial
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / therapeutic use*
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CD4 Lymphocyte Count
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Drug Therapy, Combination
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Female
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HIV Infections / drug therapy*
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HIV Infections / immunology*
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HIV Infections / virology
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HIV-1 / drug effects
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Humans
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Male
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RNA, Viral / blood
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Reverse Transcriptase Inhibitors / therapeutic use*
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Treatment Outcome
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Viral Load
Substances
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Anti-HIV Agents
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RNA, Viral
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Reverse Transcriptase Inhibitors