Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Bioorg Med Chem Lett. 2007 Feb 15;17(4):974-7. doi: 10.1016/j.bmcl.2006.11.041. Epub 2006 Nov 17.

Abstract

A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.

MeSH terms

  • Animals
  • Baculoviridae / enzymology
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / pharmacology*
  • Cell Line
  • Cell Proliferation / drug effects
  • Indicators and Reagents
  • Insulin-Like Growth Factor I / antagonists & inhibitors*
  • Mice
  • Models, Molecular
  • Phosphotransferases / antagonists & inhibitors*
  • Pyridones / pharmacology
  • Structure-Activity Relationship
  • Thymidine / metabolism

Substances

  • BMS 536924
  • Benzimidazoles
  • Indicators and Reagents
  • Pyridones
  • Insulin-Like Growth Factor I
  • Phosphotransferases
  • Thymidine