Two new taxoids from Taxus chinensis

Chem Biodivers. 2005 Oct;2(10):1316-9. doi: 10.1002/cbdv.200590103.

Abstract

Two new taxoids, 2,20-O-diacetyltaxumairol N (1) and 14beta-hydroxy-10-deacetyl-2-O-debenzoylbacatin III (2), were isolated from the needles and stems of Taxus chinensis. Their structures were determined on the basis of extensive 1D- and 2D-NMR-spectral analysis. Compound 1 showed weak cytotoxicity activity against T-24 (IC50 = 34 microg/ml) and QGY-7701 (IC50 = 22 microg/ml) cancer lines. Compound 2 showed no obvious cytotoxicity activity against T-24 (IC50 > 100 microg/ml) and QGY-7701 (IC50 > 100 microg/ml) cancer lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Taxoids / chemistry*
  • Taxoids / isolation & purification*
  • Taxoids / pharmacology
  • Taxus / chemistry*

Substances

  • 14-hydroxy-10-deacetyl-2-O-debenzoylbacatin III
  • 2,20-O-diacetyltaxumairol N
  • Antineoplastic Agents, Phytogenic
  • Taxoids