Abstract
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthelmintics / therapeutic use*
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Clonorchiasis / drug therapy*
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Clonorchiasis / parasitology
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Clonorchis sinensis / drug effects
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Cricetinae
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Fasciola hepatica / drug effects*
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Fascioliasis / drug therapy*
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Fascioliasis / parasitology
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Female
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Male
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Mesocricetus
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Mice
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Opisthorchis / drug effects*
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Opisthorchis / parasitology
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Phenylenediamines / therapeutic use*
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Rats
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Rats, Wistar
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Schistosoma mansoni / drug effects*
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Schistosomiasis mansoni / drug therapy*
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Schistosomiasis mansoni / parasitology*
Substances
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Anthelmintics
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Phenylenediamines
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tribendimidine