Abstract
Cognitive deficits are common in association with heart failure (HF), and it is possible that their severity is magnified by the concomitant presence of major depressive disorder (MDD). Using the Cambridge Mental Disorders of the Elderly Examination battery, the authors compared the cognitive performance of MDD-HF subjects (N=20), nondepressed HF subjects (N=23), and healthy control subjects (N=18). Scores were lower in both HF groups relative to control subjects. In the MDD-HF group, there were significant cognitive improvements after antidepressant treatment. Cognitive impairment is, therefore, significant in HF subjects with or without comorbid MDD, and it is important to recognize and treat MDD symptoms associated with HF.
Publication types
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Antidepressive Agents / adverse effects
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Antidepressive Agents / therapeutic use*
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Antidepressive Agents, Second-Generation / therapeutic use*
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Citalopram / adverse effects
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Citalopram / therapeutic use*
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Cognition Disorders / complications
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Cognition Disorders / diagnosis*
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Cognition Disorders / psychology
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Depressive Disorder, Major / complications
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Depressive Disorder, Major / drug therapy*
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Depressive Disorder, Major / psychology
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Female
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Geriatric Assessment
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Heart Failure / complications
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Heart Failure / psychology*
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Humans
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Male
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Mental Status Schedule / statistics & numerical data
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Neuropsychological Tests
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Psychometrics
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Selective Serotonin Reuptake Inhibitors / therapeutic use*
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Sertraline / adverse effects
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Sertraline / therapeutic use*
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Treatment Outcome
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Ventricular Dysfunction, Left / complications
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Ventricular Dysfunction, Left / psychology*
Substances
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Antidepressive Agents
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Antidepressive Agents, Second-Generation
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Serotonin Uptake Inhibitors
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Citalopram
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Sertraline