Hb Indianapolis [beta112 (G14) Cys-->Arg] as the probable cause of moderate hemolytic anemia and renal damage in a Brazilian patient

A Fattori; E M Kimura; D M Albuquerque; D M Oliveira; F F Costa; M F Sonati

doi:10.1002/ajh.20860

Hb Indianapolis [beta112 (G14) Cys-->Arg] as the probable cause of moderate hemolytic anemia and renal damage in a Brazilian patient

Am J Hematol. 2007 Jul;82(7):672-5. doi: 10.1002/ajh.20860.

Authors

A Fattori¹, E M Kimura, D M Albuquerque, D M Oliveira, F F Costa, M F Sonati

Affiliation

¹ Hematology and Hemotherapy Center, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

PMID: 17211844
DOI: 10.1002/ajh.20860

Abstract

Hemoglobin (Hb) Indianapolis [beta112 (G14) Cys-->Arg] is a rare and slightly unstable beta-globin variant. All carriers described to date were clinically normal with only mild reticulocytosis. We report here a case of a Brazilian patient in whom hemolytic anemia and acute renal failure were probably caused by the presence of this variant.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anemia, Hemolytic / genetics
Anemia, Hemolytic / metabolism*
Anemia, Hemolytic / pathology*
Arginine / genetics
Arginine / metabolism
Base Sequence
Brazil
Child
Child, Preschool
Cysteine / genetics*
Cysteine / metabolism
Female
Hemoglobins, Abnormal / genetics*
Hemoglobins, Abnormal / metabolism*
Humans
Kidney / metabolism*
Kidney / pathology*
Male
Molecular Sequence Data

Substances

Hemoglobins, Abnormal
hemoglobin Indianapolis
Arginine
Cysteine