Abstract
We describe a series of patients with combined factor deficiencies and von Willebrand's disease (VWD) at one haemophilia treatment centre. Although the incidence of VWD is at least 1% in the general population, combined coagulation defects have been infrequently described in the medical literature and are likely under diagnosed. This entity should be considered in patients with a known factor deficiency and either an unexpectedly severe bleeding phenotype, or bleeding that is unresponsive to factor replacement.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Bleeding Time
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Blood Coagulation Disorders, Inherited / blood
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Blood Coagulation Disorders, Inherited / complications*
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Child, Preschool
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Factor IX / analysis
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Factor VIII / analysis
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Hemorrhage / blood
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Hemorrhage / etiology*
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Humans
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Infant
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Male
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Middle Aged
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Retrospective Studies
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von Willebrand Diseases / blood
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von Willebrand Diseases / complications*
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von Willebrand Factor / analysis
Substances
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von Willebrand Factor
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Factor VIII
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Factor IX