Abstract
Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alzheimer Disease / immunology
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Alzheimer Disease / metabolism*
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Animals
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Antibodies, Monoclonal / immunology
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Antibody Specificity
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Brain / metabolism*
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Brain / ultrastructure
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Cattle
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Epitopes
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Humans
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Immune Sera / immunology
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Mice
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Nerve Tissue Proteins / immunology
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Nerve Tissue Proteins / metabolism*
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Neurofibrillary Tangles / immunology
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Rats
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tau Proteins / chemistry
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tau Proteins / immunology
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tau Proteins / metabolism*
Substances
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Antibodies, Monoclonal
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Epitopes
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Immune Sera
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MAPT protein, human
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Mapt protein, rat
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Nerve Tissue Proteins
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tau Proteins