Abstract
Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amantadine / pharmacology
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Amino Acid Sequence
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Antiviral Agents / pharmacology
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Cell Membrane / metabolism
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Cytoplasm / metabolism
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Humans
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Ion Channels / chemistry
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Ion Channels / metabolism*
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Ion Channels / physiology
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Ion Transport
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Models, Biological
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Molecular Sequence Data
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Orthomyxoviridae / physiology*
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Protons*
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Viral Matrix Proteins / chemistry
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Viral Matrix Proteins / metabolism*
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Virus Replication*
Substances
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Antiviral Agents
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Ion Channels
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M2 protein, Influenza A virus
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Protons
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Viral Matrix Proteins
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Amantadine