Abstract
The genetic structures surrounding the plasmid-carried blaOXA-23 oxacillinase gene, encoding resistance to carbapenems, were studied in Acinetobacter baumannii. ISAba1 and the novel element ISAba4 were detected upstream of the blaOXA-23 gene, providing promoter sequences for its expression. These insertion elements were likely involved in transposition processes at the origin of acquisition of this beta-lactamase gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics*
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Carbapenems / metabolism
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DNA Transposable Elements / genetics
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DNA Transposable Elements / physiology*
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Gene Expression
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Molecular Sequence Data
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism*
Substances
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Carbapenems
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DNA Transposable Elements
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beta-lactamase OXA-23
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beta-Lactamases
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oxacillinase
Associated data
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GENBANK/EF059914
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GENBANK/EF127491