The lipophilicity estimation of 5-arylidene derivatives of (2-thio)hydantoin with antimycobacterial activity

Biomed Chromatogr. 2007 Mar;21(3):291-8. doi: 10.1002/bmc.755.

Abstract

The lipophilicity of antituberculotic 5-arylidene derivatives of (thio)hydantoin, thioacetazone and isoniazid has been determined by reversed-phase thin-layer chromatography (RP-TLC). Mixtures of acetone and water (with acetone content 60-85%) were used as the mobile phase. The R(M) (relative lipophilicity) of each compound (except isoniazid) decreased linearly with the increasing concentration of acetone. The partition coefficients (log P) of the compounds were calculated by the use of eight computer programs (ClogP, KowWin, XlogP, AlogPs, CAChe, Pallas, Interactive analysis and Slipper) and compared with the experimental lipophilicity (R(M0)). According to the observations the best tools for in silico predicting log P of (2-thio)hydantoins are programs KowWin and AlogPs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemical synthesis
  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology
  • Chromatography, High Pressure Liquid / methods
  • Chromatography, Thin Layer / methods
  • Isoniazid / chemistry
  • Lipids / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Software
  • Solubility
  • Spectrophotometry, Ultraviolet / methods
  • Structure-Activity Relationship
  • Thioacetazone / chemical synthesis
  • Thioacetazone / chemistry*
  • Thioacetazone / pharmacology
  • Thiohydantoins / chemical synthesis
  • Thiohydantoins / chemistry*
  • Thiohydantoins / pharmacology

Substances

  • Antitubercular Agents
  • Lipids
  • Thiohydantoins
  • Thioacetazone
  • Isoniazid