[Serum acute phase proteins for determining disease activity of ulcerative colitis and Crohn disease]

Acta Med Austriaca. 1991;18(4):100-5.
[Article in German]

Abstract

We studied the activity assessment of ulcerative colitis and Crohn's disease by 5 acute phase reactants: C-reactive protein (CRP), alpha 1-acid glycoprotein, alpha 1 antitrypsin, haptoglobin and fibrinogen. From a large register of patients with inflammatory bowel disease (IBD) we chose randomly 91 patients: 61 with ulcerative colitis and 30 with Crohn's disease. As a reference point in the disease activity assessment we used standard clinical indices. Statistical analysis was performed by non-parametric methods: the Kruskal-Wallis and Fisher's exact test. The disease activity assessment in patients with ulcerative colitis by the index according to Powell-Tuck indicated that the patients with active disease (N = 19) had significantly higher levels of all acute phase proteins mentioned above except fibrinogen (alpha less than 0.05 to 0.001) than patients in remission (N = 42). Analysis of the same data by Fisher's exact test indicated that there had been a probability for all the proteins measured to be higher than the normal values, particullary CRP (p less than 10(-8) and the other somewhat less. In patients with Crohn's disease, the disease activity assessment was performed by 2 indices. According to "The Crohn's Disease Activity Index" (CDAI), only alpha-1 acid glycoprotein and haptoglobin (alpha less than 0.05) were higher in patients with active disease (N = 4) than in patients with remission (N = 26).(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • English Abstract

MeSH terms

  • Acute-Phase Proteins / analysis*
  • C-Reactive Protein / analysis
  • Colitis, Ulcerative / blood
  • Colitis, Ulcerative / diagnosis*
  • Crohn Disease / blood
  • Crohn Disease / diagnosis*
  • Fibrinogen / analysis
  • Follow-Up Studies
  • Haptoglobins / analysis
  • Humans
  • Orosomucoid / analysis
  • Reference Values
  • alpha 1-Antitrypsin / analysis

Substances

  • Acute-Phase Proteins
  • Haptoglobins
  • Orosomucoid
  • alpha 1-Antitrypsin
  • Fibrinogen
  • C-Reactive Protein