Abstract
A 72-year-old woman developed cardiac tamponade due to direct invasion of thymic cancer. Carboplatin was administered into the pericardial cavity two times with a total dose of 600 mg. Pericardial effusion disappeared without any toxicities. Following four cycles of systemic chemotherapy by carboplatin, doxorubicin, vincristine, cyclophosphamide (ADOC), partial response was obtained. She is alive 10 month after being given a diagnosis of cardiac tamponade. Intrapericardial administration of carboplatin is a useful therapy for control of pericardial effusion and chemosensitive cases should de identified among patients with thymic cancer.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carboplatin / administration & dosage*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / secondary
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Cardiac Tamponade / drug therapy*
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Cardiac Tamponade / etiology
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Cisplatin / administration & dosage
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Drug Administration Schedule
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Female
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Humans
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Liver Neoplasms / secondary
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Pleural Effusion, Malignant / drug therapy
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Pleural Effusion, Malignant / etiology
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Remission Induction
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Thymus Neoplasms / drug therapy*
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Thymus Neoplasms / pathology
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Vincristine / administration & dosage
Substances
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Carboplatin
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Cisplatin